Multielectrode interfaces with neural systems

Micron-scale electrodes are routinely used in experimental neuroscience, providing recording of the brain activity with resolution of single nerve pulses in individual neurons. Advances in nanofabrication techniques and integrated circuits technology resulted in fast development of large arrays of microelectrodes and dedicated front-end electronics that now can simultaneously record activity of hundreds of neurons. Such recordings can be also combined with multichannel stimulation of neural activity, either based on electrical pulses or optogenetic techniques. I will review current state-of-the art in the ultielectrode interfaces technology and discuss the design of the novel miniaturized system dedicated specifically for large-scale recording and stimulation of neural activity in the bahaving animals.